Seattle Genetics and its co-founder, Clay Siegall, are paving the way to make cancer a thing of the past.
Founded in 1998, Seattle Genetics is a research and drug development company focusing on scientific innovation with a passion for patients. They have developed a pipeline of antibody-based cancer therapies and have the first ever FDA approved antibody-drug conjugate (ADC), ADCETRIS. They are leaders in the world for ADC’s. The drug is designed for patients with Hodgkin lymphoma and works by empowering antibodies “designed to harness the targeting ability of monoclonal antibodies by linking them to cell-killing agents.” Dr. Siegall is proud of the fact that there are more than 15,000 people who have been treated with ADCETRIS. The drug is approved and used in over 50 countries.
He sees the future of drug development target on specific tumor antigens using ADC’s to eliminate cancers altogether. There are three ADC’s currently finishing clinical research to help with these measures. His goal is to “redefine the way frontline HL and mature T-cell lymphoma patients are treated by adding ADCETRIS into the standard regimens while dropping the most toxic agents.” The outlook for the other ADC’s is encouraging as well. Reports on these studies will be out soon with further study results coming next year. Research that the company is doing with ADC’s hopes to work with other forms of cancer such as leukemia, colon, breast, and many other forms of cancer.
Besides Seattle Genetics, Dr. Siegall provides on the board of other biotechnology companies, including Ultragenyx, Mirna Therapeutics, and Adler Biopharmaceuticals. His work with these companies will help to further better treatments for cancer and other high-risk medical needs.
Dr. Siegall received his undergraduate degree in Zoology from the University of Maryland and his Ph.D. in Genetics from The George Washington University. He has formerly worked with Bristol-Myers Squibb and the National Cancer Institute. He has been published over 70 times and holds 15 patents.
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